Synaptic Four Technical Reports

Technical Reports

Versioned, citable reports on architecture, standards, and reference implementations—for practitioners, not product marketing.

Browse reports About the series GitHub repository

The SF-TR series documents software and infrastructure we build: architectural decisions, validation, and operational experience in enough detail for independent review. Reports are versioned, source-controlled, and archived with DOIs.

About the series · Citation

Published reports

Each report is versioned and archived via GitHub and Zenodo.

SF-TR-2026-001

Version 1.0.3

Ferrum Architecture A GA4GH-Native Genomics Platform

2026-06-10

Ferrum implements a broad set of GA4GH APIs in one composable, on-premises-first runtime. Documents motivation, system architecture, Crypt4GH integration at the DRS layer, multi-engine WES/TES execution, HelixTest validation, and reproducible benchmarks via the Ferrum GA4GH Demo.

  • Architecture
  • GA4GH
  • FAIR
  • Crypt4GH
  • Genomics
HTML PDF DOI Source
BibTeX 
@techreport{synapticfour2026ferrum,
  author       = {{Synaptic Four}},
  title        = {Ferrum Architecture: A GA4GH-Native Genomics Platform},
  institution  = {Synaptic Four},
  number       = {SF-TR-2026-001},
  year         = {2026},
  version      = {1.0.3},
  type         = {Technical Report},
  doi          = {10.5281/zenodo.20628103},
  url          = {https://synapticfour.com/publications/sf-tr-2026-001},
  note         = {Synaptic Four Technical Report Series}
}

SF-TR-2026-002

Version 1.0.0

Ferrum Field & Edge Offline-First GA4GH Nodes for Resource-Constrained Genomics

2026-06-23

Documents Ferrum Field & Edge: embedded GA4GH runtime on SQLite and local storage, offline ferrum-meta validation, bandwidth-adaptive sync to connected hubs, long-offline authentication, residency audit chains, and pathogen surveillance workflows. Companion to SF-TR-2026-001.

  • Architecture
  • GA4GH
  • Edge
  • Offline-first
  • Field genomics
HTML PDF DOI Source
BibTeX 
@techreport{synapticfour2026ferrumfield,
  author       = {{Synaptic Four}},
  title        = {Ferrum Field & Edge: Offline-First GA4GH Nodes for Resource-Constrained Genomics},
  institution  = {Synaptic Four},
  number       = {SF-TR-2026-002},
  year         = {2026},
  version      = {1.0.0},
  type         = {Technical Report},
  doi          = {10.5281/zenodo.20812669},
  url          = {https://synapticfour.com/publications/sf-tr-2026-002},
  note         = {Synaptic Four Technical Report Series}
}

Related documents

Earlier whitepapers and research notes remain available. Canonical technical reports supersede informal web summaries.